Research Studies

View results of our latest research studies
(Publications pending) 

STUDY ONE

Population

Competitive golfers during a 150-yard hitting task.

Device and Treatment Duration

P57 first generation prototype 10 minutes of vagus and great auricular nerve stimulation on both sides of neck (bilateral stimulation).

Results

36%

Clinically Significant Reduction (36%) in anxiety in active treatment group after single 10-min treatment.

18%

Reduction in anxiety in sham group.
Significant improvement in “feel” of each shot in active group alone.
No differences in safety and tolerability between active and sham treatments.

Pain, dizziness, blurred vision, headache, skin itching or irritation.

STUDY TWO

Population

Patients with self-diagnosed Post Traumatic Stress Disorder and Panic Disorder

Device and Treatment Duration

P57 ONE handheld device, 5-minutes of self-applied treatment on each side of the neck for a 10-minute total treatment time (unilateral stimulation)

Results

24%

Clinically Significant Reduction  in State-Anxiety in active treatment group after single treatment

Non-significant improvement in sham group

31%

Active patients found treatment to be relaxing
Increase in Heart Rate Variability in active group alone.

0% change in sham group.

100%

Active patients found treatment to be relaxing

Of Active Users reported treatment to be "Relaxing."

33% of sham participants found treatment to be relaxing

No differences in safety and tolerability between active and sham treatments.

Pain, dizziness, blurred vision, headache, skin itching or irritation.

CASE STUDY

Population

A 23 year-old-male with severe panic attacks and anxiety

Device and Treatment Duration

Hoolest bilateral and unilateral stimulation device comparison.

Use 2x per day for 8 weeks.

After 8 weeks of using the devices, patient was asked to rate each statement as Strongly Agree, Agree, Neutral, Disagree, or Strongly Disagree.

Results

"I feel better after using the device"
Strongly Agree

63%

of the time.
Agree

37%

of the time.
"The device decreases the severity of my symptoms"
Agree

75%

of the time.
Neutral

25%

of the time.
"I felt better having access to this device in case I have symptoms"
Strongly Agree

25%

of the time.
Agree

75%

Agree
"The Device is easy to use"
Strongly Agree

12.5%

of the time.
Agree

75%

of the time.
"The Device helps me relax"
Strongly Agree

37%

of the time.
Agree

63%

of the time.
Patient Statement:“It has stopped some panic attacks from getting worse and [felt like] I was melting into my bed. Complete mental and physical relaxation.”

Additional Applications with P57 ONE

Trigeminal Nerve

Applying external stimulation to the Trigeminal nerve has been proven for acute migraine relief and prevention.
View Reference Device

Median Nerve

Applying external stimulation to the Median nerve has been proven for acute nausea and motion sickness relief.
View Reference Device

For full product information and research manuscripts, submit an inquiry to request our product whitepaper

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